Anti-Anxiety Drugs

Side Effects Studies

Addiction
Alzheimer’s
Miscarriages
Pneumonia

Addiction/Withdrawal

The benzodiazepine withdrawal syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/7841856
Addiction. 1994 Nov;89(11):1455-9
Physiological dependence on benzodiazepines is accompanied by a withdrawal syndrome which is typically characterized by sleep disturbance, irritability, increased tension and anxiety, panic attacks, hand tremor, sweating, difficulty in concentration, dry wretching and nausea, some weight loss, palpitations, headache, muscular pain and stiffness and a host of perceptual changes. Instances are also reported within the high-dosage category of more serious developments such as seizures and psychotic reactions. Withdrawal from normal dosage benzodiazepine treatment can result in a number of symptomatic patterns. .. Physiological dependence on benzodiazepines can occur following prolonged treatment with therapeutic doses, but it is not clear what proportion of patients are likely to experience a withdrawal syndrome. It is also unknown to what extent the risk of physiological dependence is dependent upon a minimum duration of exposure or dosage of these drugs. Withdrawal phenomena appear to be more severe following withdrawal from high doses or short-acting benzodiazepines…

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Alzheimer’s

Benzodiazepine use and risk of Alzheimer’s disease: case-control study
http://www.bmj.com/content/349/bmj.g5205British Medical Journal
9 September 2014
Conclusion Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern.

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Miscarriages

Benzodiazepines in Early Pregnancy Up Miscarriage Risk
MedPage 2019
https://www.medpagetoday.com/obgyn/pregnancy/79855

“Use of benzodiazepine agents in early pregnancy was associated with increased risk of spontaneous abortion, according to a nested case-control study.”

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Pneumonia

Benzodiazepines or related drugs and risk of pneumonia: A systematic review and metaanalysis
https://onlinelibrary.wiley.com/doi/full/10.1002/gps.5048

2019 International Journal of Geriatric Psychiatry

Conclusion
Current or recent exposure to Benzodiazepines and benzodiazepine‐related drugs is associated with an increased pneumonia risk. Clinicians need to weight the benefit‐risk balance of BZRD use, especially those with other risk factors for pneumonia.

 


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